Histone Deacetylase Inhibitor I3 Induces the Differentiation of Acute Myeloid Leukemia Cells with <i>t</i> (8; 21) or MLL Gene Translocation and Leukemic Stem-Like Cells

<div>I3 promotes cell differentiation via the downregulation of the VEGF signaling pathway. (a) Volcano plots of Kasumi-1 cells. (b) The heatmap of DEGs. The heatmap bars from blue to red represent the expression levels of DEGs from low to high. (c) The significantly enriched pathways. Kasumi-1 cells were incubated with 0.25 <i>μ</i>M of I3 for 72 h.</div>

Journal of Oncology

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Figure 6

Figure 6: Histone Deacetylase Inhibitor I3 Induces the Differentiation of Acute Myeloid Leukemia Cells with <i>t</i> (8; 21) or MLL Gene Translocation and Leukemic Stem-Like Cells 

Figure 6 | Histone Deacetylase Inhibitor I3 Induces the Differentiation of Acute Myeloid Leukemia Cells with t (8; 21) or MLL Gene Translocation and Leukemic Stem-Like Cells 