SNHG3 Affects Gastric Cancer Development by Regulating SEPT9 Methylation

Figure 3

Targeting correlation between SNHG3 and miR-448 and between DNMT1 and miR-448. (a) Binding site between SNHG3 and miR-448; (b) binding site between miR-448 and DNMT1; (c) dual-luciferase reporter gene experiment to evaluate the luciferase activity of transfected NC mimic/miR-448 mimic and SNHG3 WT/MUT; (d) dual-luciferase gene experiment to evaluate the luciferase activity of transfected NC mimic/miR-448 mimic and DNMT1 WT/MUT; (e) qRT–PCR detection of the expression of SNHG3 after transfection of the NC mimic/miR-448 mimic; (f) qRT–PCR detection of the expression of DNMT1 after transfection of the NC inhibitor/miR-448 inhibitor. based on comparisons with the NC group.

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