Blocking TGF-β Expression Attenuates Tumor Growth in Lung Cancers, Potentially Mediated by Skewing Development of Neutrophils

<div>Predicted plasma TGF-β1 concentration and TGF-β1 concentration in vitro (a) Blood TGF-β1 concentration in TGF-β1 knockout mice is reduced compared with wild-type mice. In addition, the TGF-β1 concentration of mice with injection of purified TGF-β1 is significantly higher than that of wild-type mice. (b) Compared with the wild-type mice, there is no significant decrease in blood TGF-β1 concentration in the TGF-β1 knockout group, indicating that the gene knockout model is not successful.</div>

Journal of Oncology

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Figure 1

Figure 1: Blocking TGF-β Expression Attenuates Tumor Growth in Lung Cancers, Potentially Mediated by Skewing Development of Neutrophils