Pancreatic Cancer-Derived Exosomes Promote the Proliferation, Invasion, and Metastasis of Pancreatic Cancer by the miR-3960/TFAP2A Axis

<div>The identification of PANC-1-derived exosomes. (<span class="nowrap"><svg height="9.67738pt" id="M5" style="vertical-align:-0.3499298pt" version="1.1" viewbox="-0.0498162 -9.32745 26.358 9.67738" width="26.358pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><rect height="0.65243" width="7.47692" x="0" y="-8.6252"></rect><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M552 399C552 425 539 454 501 454C451 454 411 416 332 310L314 361C295 415 272 454 241 454C202 454 143 409 83 325L106 298C141 343 161 356 170 356C182 356 194 353 216 283L240 205C186 131 142 82 117 82C108 82 103 85 92 94C86 99 78 104 71 104C47 104 21 82 21 48S46 -12 78 -12C135 -12 174 38 256 161L281 89C306 16 325 -12 364 -12S468 27 529 120L509 149C465 97 443 83 430 83C416 83 404 107 392 140L346 271C370 300 392 326 410 343C430 360 443 367 455 367C465 367 474 363 480 356S492 345 500 345C522 345 552 365 552 399Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.382,0)"><path d="M535 290V340H323V533H265V340H52V290H265V84H323V290H535ZM535 -22V28H52V-22H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,20.919,0)"><path d="M386 382C386 422 341 454 281 454C239 454 191 429 152 402C103 368 86 331 86 294C86 233 150 188 200 160C257 128 270 106 270 89C270 68 251 52 222 52C184 52 134 88 92 134C82 145 75 144 58 135C39 125 21 100 21 76C21 27 89 -12 154 -12C239 -12 362 60 362 151C362 209 318 247 257 280C220 300 179 327 179 355C179 375 192 390 219 390C263 390 295 362 318 327C325 317 336 317 347 324C370 339 386 361 386 382Z"></path></g></svg>,</span> <i>n</i> =3). (a) Transmission electron microscopy. (Scale bar =200 nm) (b and c) Nanoparticle Tracking analysis. (d) The average levels of TSG101, Alix, CD81, CD9, CD63, HSP70 and C-myc. <svg height="10.1524pt" id="M6" style="vertical-align:-0.04990005pt" version="1.1" viewbox="-0.0498162 -10.1025 11.7596 10.1524" width="11.7596pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 148 486 158Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,5.56,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 148 486 158Z"></path></g></svg><i>P</i> &lt;0.01 compared to the cell group.</div>

Journal of Oncology

fig2

Figure 2

Figure 2: Pancreatic Cancer-Derived Exosomes Promote the Proliferation, Invasion, and Metastasis of Pancreatic Cancer by the miR-3960/TFAP2A Axis 