SHC1 Promotes Lung Cancer Metastasis by Interacting with EGFR

Figure 3

Knockdown of SHC1 inhibits lung cancer EMT in A549 and NCI–H446 cells. (a) In A549 and NCI–H446 cells, the expression of E-cadherin when SHC1 knockdown was detected by qRT-PCR. (b) In A549 and NCI–H446 cells, the expression of vimentin when SHC1 knockdown was detected by qRT-PCR. (c) In A549 and NCI–H446 cells, the expression of E-cadherin and vimentin during SHC1 knockdown was detected by immunofluorescence. (d) Statistical analysis results of the changes in the expression of E-cadherin and vimentin. Data are shown as the mean ± SEM; n = 3 independent experiments, .

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