SHC1 Promotes Lung Cancer Metastasis by Interacting with EGFR

Figure 6

Overexpression of EGFR and SHC1 promotes the expression of tumor-related transcription factors. (a) In NCI–H446 and A549 cells, the expression of Twsit1 after overexpression of EGFR and SHC1 was detected by qRT-PCR. (b) In NCI–H446 and A549 cells, the expression of Twsit2 after overexpression of EGFR and SHC1 was detected by qRT-PCR. (c) In NCI–H446 and A549 cells, the expression of Snail1 after overexpression of EGFR and SHC1 was detected by qRT-PCR. (d) In NCI–H446 and A549 cells, the expression of Slug after overexpression of EGFR and SHC1 was detected by qRT-PCR. (e) In NCI–H446 and A549 cells, the expression of ZEB1 after overexpression of EGFR and SHC1 was detected by qRT-PCR. (f) In NCI–H446 and A549 cells, the expression of ZEB2 after overexpression of EGFR and SHC1 was detected by qRT-PCR. Data are shown as the mean ± SEM; n = 3 independent experiments, .

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