Long-Term Evaluation and Normal Tissue Complication Probability (NTCP) Models for Predicting Radiation-Induced Optic Neuropathy after Intensity-Modulated Radiation Therapy (IMRT) for Nasopharyngeal Carcinoma: A Large Retrospective Study in China

<div>The time-dependent receiver operating characteristic (ROC) curve (a) and dose-effect curves (b) of Dmax for RION. Dmax had the highest AUC value at 8 years with 0.9434. The optimal cutoff of Dmax was 64.48 Gy (sensitivity = 0.955; specificity = 0.814). Solid and dashed lines indicate logistic regression and the 95% CI dose tolerance, respectively. RION = radiation-induced optic neuropathy; <i>D</i>max = maximum point dose; AUC = area under the receiver operating characteristic curve; CI = confidence intervals.</div>

Journal of Oncology

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Figure 2: Long-Term Evaluation and Normal Tissue Complication Probability (NTCP) Models for Predicting Radiation-Induced Optic Neuropathy after Intensity-Modulated Radiation Therapy (IMRT) for Nasopharyngeal Carcinoma: A Large Retrospective Study in China 

Figure 2 | Long-Term Evaluation and Normal Tissue Complication Probability (NTCP) Models for Predicting Radiation-Induced Optic Neuropathy after Intensity-Modulated Radiation Therapy (IMRT) for Nasopharyngeal Carcinoma: A Large Retrospective Study in China 