Research Article

Hsa_circ_0000520 Promotes Non-Small Cell Lung Cancer Progression through the miR-1258/AKT3 Axis

Figure 2

Circ_0000520 promotes NSCLC cell proliferation, migration, and invasion. (a) After transfecting pcDNA3.1-circ_0000520 or pcDNA3.1-NC into A549 and H460 cells, qPCR was carried out to detect the circ_0000520 expression in A549 and H460 cells. (b, c) CCK-8 method and EdU assay were utilized to detect the effect of circ_0000520 overexpression on A549 and H460 cell proliferation. (d) Transwell assays were utilized to detect the effects of circ_0000520 overexpression on A549 and H460 cell migration and invasion. (e) A transplanted tumor model was used to evaluate the effect of circ_0000520 overexpression on tumor growth in vivo. and .
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