Outcomes of Patients with Metastatic Colorectal Cancer Treated with Trifluridine/Tipiracil beyond the Second Line: A Multicenter Retrospective Study from Saudi Arabia

Table 4

Mortality predictors among the studied cohort: logistic regression analysis.

Variable	Multivariate
	OR (95% CI)	value
Age (≥55 years)	1.675 (0.755–3.718)	0.205
Sex (male)	0.804 (0.361–1.787)	0.592
Advanced disease stage (III–IV)	2.245 (1.014–5.161)	0.048
Prior adjuvant chemotherapy	0.926 (0.408–0.991)	0.045
Lymph node metastasis	2.465 (1.078–5.638)	0.033
Liver metastasis	2.906 (1.115–7.579)	0.029
Number of metastatic sites (≥2)	1.554 (1.041–2.618)	0.045
Duration since diagnosis (≥30 months)	0.590 (0.258–0.804)	0.036
Neutropenia after first cycle of FTD/TPI	0.597 (0.269–0.954)	0.046
Number of FTD/TPI cycles	0.832 (0.707–0.978)	0.026

OR: odds ratio; CI: confidence interval; FTD/TPI: trifluridine/tipiracil.