Outcomes of Patients with Metastatic Colorectal Cancer Treated with Trifluridine/Tipiracil beyond the Second Line: A Multicenter Retrospective Study from Saudi Arabia

Table 5

Cox hazard regression of the independent overall survival predictors.

	value	HR	95% CI
			Lower	Upper
Age (≥55 years)	0.046	1.667	1.097	3.100
Sex (male)	0.457	0.891	0.656	1.208
Stage (III–IV)	0.044	1.283	1.035	2.940
Prior adjuvant chemotherapy	0.037	0.892	0.481	0.994
Lymph node metastasis	0.147	1.514	0.865	2.650
Liver metastasis	0.025	2.015	1.091	3.720
Number of metastatic sites (≥2)	0.038	1.248	1.036	1.846
Duration since diagnosis (≥30 months)	0.145	0.992	0.974	1.011
Neutropenia after first cycle of FTD/TPI	0.039	0.633	1.064	2.167
Number of FTD/TPI cycles	0.002	0.769	0.664	0.891

HR: hazard ratio; CI: confidence interval; FTD/TPI: trifluridine/tipiracil.