Identification of a 5-Hydroxymethylation Signature in Circulating Cell-Free DNA for the Noninvasive Detection of Colorectal Cancer

Table 2

GO analysis of the DEG and genes in the highly correlated modules.

GO ID	Description	value	No. genes
Upregulated genes
GO:0035580	Specific granule lumen	2.83E-06	5
GO:0043312	Neutrophil degranulation	8.04E-06	10
GO:0002283	Neutrophil activation involved in immune response	8.44E-06	10
GO:0002446	Neutrophil-mediated immunity	1.00E-05	10
GO:0042119	Neutrophil activation	1.00E-05	10
GO:0036230	Granulocyte activation	1.12E-05	10
GO:0043299	Leukocyte degranulation	1.81E-05	10
GO:0042581	Specific granule	1.97E-05	6
GO:0034774	Secretory granule lumen	2.00E-05	8
GO:0060205	Cytoplasmic vesicle lumen	2.16E-05	8
GO:0002275	Myeloid cell activation involved in immune response	2.18E-05	10
GO:0031983	Vesicle lumen	2.25E-05	8
GO:0002444	Myeloid leukocyte-mediated immunity	2.41E-05	10
GO:0002274	Myeloid leukocyte activation	9.22E-05	10
GO:0030141	Secretory granule	1.58E-04	11
GO:0002366	Leukocyte activation involved in immune response	1.76E-04	10
GO:0002263	Cell activation involved in immune response	1.85E-04	10
GO:0031960	Response to corticosteroid	3.83E-04	5
GO:0045055	Regulated exocytosis	4.58E-04	10
GO:0099503	Secretory vesicle	6.86E-04	11
GO:0002443	Leukocyte-mediated immunity	1.13E-03	10
Downregulated genes
GO:0034341	Response to interferon-gamma	2.54E-06	7
GO:0071346	Cellular response to interferon-gamma	1.92E-05	6
GO:0001909	Leukocyte-mediated cytotoxicity	2.04E-05	5
GO:0045087	Innate immune response	2.57E-05	12
GO:0098542	Defense response to other organisms	3.88E-05	13
GO:0002688	Regulation of leukocyte chemotaxis	4.38E-05	5
GO:0051270	Regulation of cellular component movement	4.70E-05	12
GO:0002685	Regulation of leukocyte migration	4.86E-05	6
GO:0002687	Positive regulation of leukocyte migration	7.21E-05	5
GO:0002699	Positive regulation of immune effector process	7.40E-05	6
GO:0002697	Regulation of immune effector process	9.47E-05	8
GO:2000145	Regulation of cell motility	1.01E-04	11
GO:0040012	Regulation of locomotion	1.46E-04	11
GO:0002703	Regulation of leukocyte-mediated immunity	4.34E-04	5
GO:0050920	Regulation of chemotaxis	6.42E-04	5
GO:0030595	Leukocyte chemotaxis	7.56E-04	5
GO:0004930	G protein-coupled receptor activity	9.04E-04	9
GO:0032103	Positive regulation of response to external stimulus	9.04E-04	7
GO:0030335	Positive regulation of cell migration	1.03E-03	7
GO:2000147	Positive regulation of cell motility	1.31E-03	7
GO:0040017	Positive regulation of locomotion	1.53E-03	7

Notes. GO, Gene Ontology; DEG, differentially expressed genes.