Identification of a 5-Hydroxymethylation Signature in Circulating Cell-Free DNA for the Noninvasive Detection of Colorectal Cancer

Table 3

KEGG and Reactome pathway enrichment analyses of the DEG and genes in the highly correlated modules.

ID	Description	value	NES_abs
hsa04611	Platelet activation	1.96E-03	1.82
hsa00480	Glutathione metabolism	2.02E-03	1.72
hsa05414	Dilated cardiomyopathy	2.01E-03	1.70
hsa04662	B-cell receptor signaling pathway	2.00E-03	1.69
hsa04062	Chemokine signaling pathway	2.10E-03	1.65
hsa01524	Platinum drug resistance	5.93E-03	1.65
hsa04650	Natural killer cell-mediated cytotoxicity	2.00E-03	1.63
hsa00410	Beta-alanine metabolism	3.75E-02	1.57
hsa00670	One carbon pool by folate	2.94E-02	1.51
hsa04060	Cytokine–cytokine receptor interaction	3.96E-03	1.51
hsa04550	Signaling pathways regulating pluripotency of stem cells	8.08E-03	1.49
hsa00515	Mannose type O-glycan biosynthesis	4.70E-02	1.48
hsa02010	ABC transporters	3.43E-02	1.47

Abbreviations. KEGG, Kyoto Encyclopedia of Genes and Genomes; DEG, differentially expressed genes.