More Liver Metastases Detected Intraoperatively Indicates Worse Prognosis for Colorectal Liver Metastases Patients after Resection Combined with Microwave Ablation
Table 2
Prognostic factors for overall survival and recurrence-free survival.
Variable
Overall survival
Recurrence-free survival
Univariate analysis
Multivariate analysis
Univariate analysis
Multivariate analysis
HR (95% CI)
value
HR (95% CI)
value
HR (95% CI)
value
HR (95% CI)
value
Age> 55 y
1.13 (0.48-2.67)
0.784
0.76 (0.42-1.37)
0.354
Male
0.68 (0.28-1.62)
0.380
0.42 (0.23-0.77)
0.005
Primary tumor
Rectum cancer
0.87 (0.35-2.17)
0.762
0.56 (0.28-1.14)
0.112
T3/T4 stage
0.76 (0.10-5.79)
0.789
1.50 (0.36-6.23)
0.581
N1/N2 stage
1.98 (0.63-6.20)
0.240
1.16 (0.60-2.26)
0.658
TNM III/IV stage
0.99 (0.55-1.77)
0.962
1.19 (0.79-1.80)
0.402
Resection with CRLM
0.65(0.24-1.80)
0.410
0.85 (0.46-1.57)
0.608
CRLM
Synchronous metastases
1.13 (0.41-3.11)
0.817
1.12 (0.52-2.40)
0.781
μg/L
1.25 (0.17-9.51)
0.827
1.11 (0.39-3.10)
0.850
CA19-9> 35 kU/L
3.67 (1.55-8.70)
0.003
4.29 (1.77-10.37)
0.001
1.40 (0.74-2.60)
0.302
Tumor number in image >5
1.12 (0.47-2.68)
0.799
1.27 (0.70-2.29)
0.436
Tumor number in surgery >5
1.90 (0.78-4.63)
0.158
1.95 (1.07-3.56)
0.030
1.95 (1.07-3.56)
0.030
More tumor number than image
2.61 (1.08-6.28)
0.027
3.19 (1.28-7.97)
0.013
1.62 (-/88-2.97)
0.122
Tumor size >5cm
4.36 (0.96-19.7)
0.056
1.57 (0.56-4.42)
0.392
R0 resection
2.06 (0.66-6.41)
0.211
CRS score 3-5
1.63 (0.68-3.91)
0.276
1.18 (0.65-2.15)
0.580
HR = hazard ratio; CI = confidence interval; T stage = tumor stage; N stage = node stage; TNM stage = tumor node metastasis stage; CRLM = colorectal liver metastases; CEA = carcinoembryonic antigen; CA19-9 = carbohydrate antigen 19-9; R0 resection = hepatectomy on patients with clear histological margins; CRS = clinical risk score; .
