hsa_circ_0077837 Alleviated the Malignancy of Non-Small Cell Lung Cancer by Regulating the miR-1178-3p/APITD1 Axis

<div>Hsa_circ_0077837 inhibited NSCLC cell viability, migration, and invasion and enhanced apoptosis. (a) The expression of hsa_circ_0077837 was significantly elevated or decreased in H1650 cells by transfection with over-hsa_circ_0077837 or si-hsa_circ_0077837, respectively; GAPDH acted as a control. (b) CCK-8 assay detected H1650 cell viability after transfection. (c, d) Transwell and would healing assays detected H1650 cell invasive and migratory abilities in over-hsa_circ_0077837 and si-hsa_circ_0077837 groups. (e) Flow cytometry detected the apoptosis rate. The data were presented as mean ± SEM, <span class="nowrap"><svg height="11.6791pt" id="M10" style="vertical-align:-1.5766pt" version="1.1" viewbox="-0.0498162 -10.1025 132.073 11.6791" width="132.073pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 148 486 158Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,5.56,-5.741)"><path d="M486 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Journal of Oncology

fig2

Figure 2

Figure 2: hsa_circ_0077837 Alleviated the Malignancy of Non-Small Cell Lung Cancer by Regulating the miR-1178-3p/APITD1 Axis 