Circular RNA hsa_circ_0004543 Aggravates Cervical Cancer Development by Sponging MicroRNA hsa-miR-217 to Upregulate Hypoxia-Inducible Factor

Figure 1

hsa_circ_0004543 was amplified in cervical cancer tissue and cells. hsa_circ_0004543 expression was determined with quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). (a) The hsa_circ_0004543 expression was considerably upregulated in CC patient tissues compared with paired paracancerous normal tissues (NC) (n = 40). (b) The hsa_circ_0004543 expression was considerably upregulated in CC cells (SiHa, CaSki, C-4I, C-33A, SW756, and HeLa) compared with End1/E6E7 (normal human cervical epithelial cells) ( < 0.05,  < 0.01, and  < 0.001).

(a)

(b)