ATAXIC: An Algorithm to Quantify Transcriptomic Perturbation Heterogeneity in Single Cancer Cells

Figure 6

Correlations of ATAXIC scores with clinical characteristics. ATAXIC scores are higher in metastatic versus primary tumors (a), in late-stage versus early-stage tumors (b), in higher-grade (G4) versus lower-grade (G3) tumors (c), and in progressive versus regressive or stable tumors (d). (e) ATAXIC scores are lower in the tumors treated with VEGF inhibitors than those not treated with them and lower in the tumors treated with immune checkpoint inhibitors (ICIs) than those not treated with them in RCC. (f) ATAXIC scores are lower in the tumors responsive to ICIs versus the tumors not responsive to ICIs in RCC. (g) ATAXIC scores are lower in smoker than in nonsmoker lung cancers. The one-tailed Mann–Whitney U test P values are shown.

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