Research Article
The Prognostic Significance of HALP Index for Colon Cancer Patients in a Hispanic-Based Population
Table 3
Univariate and multivariate analyses for factors associated with disease-free survival.
| | | Total (events) | Median (95% CI) | value | HR (95% CI) | value |
| | Age (yr) | | | 0.705 | | | | <65 | 455 (97) | 74.3 (69.5–79.0) | | | | | ≥65 | 185 (34) | 78.4 (71.5–85.2) | | | | | Sex | | | 0.904 | | | | Female | 319 (66) | 74.3 (68.6–79.9) | | | | | Male | 321 (65) | 76.1 (70.8–81.3) | | | | | pTNM stage | | | <0.001 | | 0.136 | | I | 75 (6) | 88.1 (78.8–97.3) | | 1.963 (0.809–4.762) | | | II | 276 (34) | 86.8 (82.3–91.3) | | | | | III | 289 (91) | 61.0 (54.3–67.6) | | | | | Tumor differentiation | | | 0.001 | | 0.125 | | Well and moderate | 483 (89) | 78.4 (73.9–82.5) | | 1.169 (0.958–1.426) | | | Poor | 157 (42) | 65.7 (56.3–75.1) | | | | | Lymphovascular invasion | | | <0.001 | | 0.436 | | No | 421 (67) | 81.2 (76.9–85.5) | | 1.175 (0.783–1.763) | | | Yes | 219 (64) | 63.7 (56.0–71.3) | | | | | Perineural invasion | | | <0.001 | | 0.056 | | No | 523 (93) | 79.0 (74.8–83.1) | | 1.473 (0.961–2.260) | | | Yes | 117 (38) | 56.3 (44.7–67.8) | | | | | CCI | | | 0.616 | | | | 0 | 180 (37) | 76.3 (69.4–83.1) | | | | | ≥I | 460 (94) | 74.7 (69.9–79.4) | | | | | Cancer obstruction | | | 0.186 | | | | No | 562 (108) | 75.9 (71.8–80.0) | | | | | Yes | 78 (23) | 70.5 (59.7–81.2) | | | | | Cancer perforation | | | 0.002 | | 0.046 | | No | 583 (111) | 77.1 (73.1–81.0) | | 1.692 (0.986–2.902) | | | Yes | 57 (20) | 56.7 (41.6–71.8) | | | | | Number of resected lymph nodes | | | 0.156 | | | | <12 | 95 (26) | 69.0 (59.-78.9) | | | | | ≥12 | 545 (105) | 76.4 (72.0–80.7) | | | | | Pathology N stage | | | <0.001 | | 0.793 | | N negative | 357 (42) | 86.5 (82.4–90.6) | | 1.150 (0.405–3.2689) | | | N positive | 283 (89) | 61.3 (54.6–67.9) | | | | | Surgical margins/type of resection | | | 0.001 | | 0.138 | | R0 | 626 (124) | 75.9 (71.6–80.2) | | 1.926 (0.810–4.575) | | | R1/R2 | 14 (7) | 47.6 (20.5–74.6) | | | | | HALP score | | | 0.452 | | 0.536 | | <15 | 163 (35) | 71.2 (62.0–80.4) | | 1.134 (0.761–1.690) | | | ≥15.0 | 477 (96) | 75.8 (71.3–80.3) | | | |
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HALP: hemoglobin (g/L) × albumin (g/L) × lymphocytes (/L)/platelets (/L), BMI: body mass index, pTNM: pathological tumor-node-metastasis stage, CCI: Charlson comorbidity index.
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