EGFR-AS1 Promotes Nonsmall Cell Lung Cancer (NSCLC) Progression via Downregulating the miR-524-5p/DRAM1 Axis and Inhibiting Autophagic Lysosomal Degradation

Figure 4

The expression of miR-524-5p is negatively correlated with DRAM1 expression. (a) In silico prediction of the potential targets of miR-524-5p. (b) The binding of miR-524-5p on DRAM1 was revealed by luciferase reporter assay. The unpaired-student t test was applied. (c) The expression level of DRAM1 in 50 samples of normal lung tissues and NSCLC tissues. The paired-student t test was applied. (d) The expression level of DRAM1 in normal lung cells and NSCLC cells. One-way ANOVA was applied. (e) There was a negative correlation between the expression of DRAM1 and miR-524-5p. Spearman’s correlation analysis was conducted. The data are represented as mean ± S.D.  < 0.05,  < 0.01, and  < 0.001.

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