Comprehensive Network Analysis Identified SIRT7, NTRK2, and CHI3L1 as New Potential Markers for Intervertebral Disc Degeneration

Figure 2

Identification of IDD-related modules. (a) Expression distribution in each sample in the combined dataset of GSE56081 and GSE124272. Blue is the GSE56081 dataset sample, Red is the GSE124272 dataset sample. (b) Expression distribution in each sample in GSE56081 and GSE124272 datasets after removing batch effect, Blue is the GSE56081 dataset sample, Red is the GSE124272 dataset sample. (c) Analysis of the scale-free fit index for various soft-thresholding powers (β). (d) Analysis of the mean connectivity for various soft-thresholding powers. (e) Dendrogram of all expressed genes clustered based on a dissimilarity measure (1-TOM). (f) The correlation between co-expression module and IDD, where the upper right corner represents significant value, and the lower left corner represents correlation coefficient, , , and . The number in parentheses is the number of genes in the module. (g) The difference distribution of the feature vectors of modules that are significantly related to IDD in IDD and the control group.

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