Proposed Models for Prediction of Mortality in Stage-I and Stage-II Gastric Cancer and 5 Years after Radical Gastrectomy
Table 3
Prognosis factors of patients in Groups A and B by univariate and multivariate cox regression analysis.
Characteristics
Group A
Group B
Univariate analysis
Multivariate analysis
Univariate analysis
Multivariate analysis
Or (95% CI)
P value
Or (95% CI)
P value
Or (95% CI)
P value
Or (95% CI)
P value
Sex
0.073
—
—
0.445
—
—
Male
1
1
Female
2.009 (0.938–4.305)
1.263 (0.694–2.300)
Age (years)
1.034 (1.004–1.066)
0.027
1.022 (0.989–1.056)
0.196
1.069 (1.040–1.098)
＜0.001
1.070 (1.037–1.105)
＜0.001
Fibrinogen
1.909 (1.336–2.728)
＜0.001
1.547 (1.041–2.300)
0.031
1.556 (1.201–2.017)
0.001
1.268 (1.042–1.544)
0.018
SII
1.001 (1.000–1.002)
0.002
1.001 (1.000–1.002)
0.039
1.003 (1.002–1.004)
＜0.001
1.003 (1.002–1.004)
＜0.001
BMI
0.958 (0.866–1.061)
0.412
—
—
0.897 (0.822–0.980)
0.016
0.911 (0.821–1.009)
0.075
Borrmann type
0.897
—
—
0.014
0.165
0
1
1
1
1
0.667 (0.104–4.261)
0.668
5.619 (0.484–65.218)
0.168
2.806 (0.188–41.846)
0.454
2
1.000 (0.291–3.432)
1.000
11.579 (1.519–88.265)
0.018
6.647 (0.742–59.542)
0.090
3
0.943 (0.298–2.985)
0.920
17.481 (2.360–129.505)
0.005
9.346 (1.074–81.364)
0.043
4
0.364 (0.036–3.707)
0.393
27.231 (3.016–245.887)
0.003
12.220 (1.014–147.266)
0.049
Tumor location
0.342
—
—
＜0.001
0.844
Lower and entire third
1
1
1
Middle third
1.619 (0.807–3.250)
0.175
2.705 (1.395–5.246)
0.003
1.148 (0.447–2.952)
0.774
Upper third
1.451 (0.583–3.608)
0.424
3.027 (1.520–6.029)
0.002
0.817 (0.227–2.949)
0.758
Tumor diameter (mm)
1.025 (1.011–1.039)
0.001
1.009 (0.993–1.026)
0.281
1.023 (1.012–1034)
＜0.001
0.996 (0.981–1.012)
0.641
Scope of gastrectomy
0.051
0.547
＜0.001
0.035
Distal gastrectomy
1
1
1
1
Proximal gastrectomy
0.435 (0.223–0.850)
0.015
1.524 (0.503–4.618)
0.457
4.711 (2.311–9.605)
＜0.001
4.846 (1.277–18.394)
0.020
Total gastrectomy
0.521 (0.169–1.607)
0.257
1.435 (0.658–3.130)
0.363
2.973 (1.571–5.629)
0.001
2.868 (1.114–7.383)
0.029
Lymph node metastasis rate (%)
3.871 (0.872–17.182)
0.075
—
—
15.462 (0.938–254.878)
0.055
—
—
pTNM stage
＜0.001
0.019
＜0.001
0.169
I
1
1
1
1
II
5.570 (1.834–16.918)
0.002
3.530 (1.117–11.156)
0.032
5.487 (2.656–11.332)
1.833 (0.774–4.344)
III
8.500 (2.893–24.975)
＜0.001
5.161 (1.642–16.225)
0.005
—
—
—
—
Histological type
0.764
—
—
0.221
—
—
Well and moderately differentiated
1
1
Poorly differentiated
1.094 (0.375–3.189)
0.870
1.588 (0.937–2.690)
0.086
Others
0.876 (0.305–2.515)
0.806
1.413 (0.641–3.115)
0.392
H. pylori infection
1.058 (0.433–2.583)
0.902
—
—
0.672 (0.301–1.499)
0.331
—
—
aBased on the eighth edition of the AJCC Cancer Staging Manual of the American Joint Committee on Cancer. Statistically significant P values are in bold ().
