MiRNA-196-5p Promotes Proliferation and Migration in Cholangiocarcinoma via HAND1/Wnt/β-Catenin Signaling Pathway

Table 1

Expression levels of miR-196-5p and HAND1 in CCA patients.

Characteristics	Number	miR-196-5p expression			HAND1 expression
		High group	Low group		High group	Low group
Gender
Female	26	14	12	0.472	11	15	0.410
Male	30	19	11		16	14
Age (years)
< 60	24	10	14	0.280	15	9	0.352
≥ 60	32	18	14		16	16
Tumor size
< 5 cm	25	7	18	0.043	18	7	0.013
≥ 5 cm	31	17	14		12	19
Metastasis
Present	26	6	20	0.010	12	14	0.016
Absent	30	17	13		5	25
TNM stage
I-II	19	4	15	0.019	12	5	0.003
III-IV	37	22	15		10	27

Expression level of miR-196 and HAND1 were correlated with tumor size, metastasis, and TNM stage in 56 CCA patients (chi-square test).