Aspirin Suppressed PD-L1 Expression through Suppressing KAT5 and Subsequently Inhibited PD-1 and PD-L1 Signaling to Attenuate OC Development

Figure 3

Aspirin suppresses IFN-γ-stimulated PD-L1 expression in OC cells. (a and b) TOV-21G and SKOV-3 cells were stimulated with IFN-γ at a dose of 200 ng/mL, and then level of PD-L1 was measured by using FACS assay. (c and d) The level of PD-L1 in TOV-21G and SKOV-3 cells under treatment with IFN-γ alone or together with aspirin was assessed by FACS. (e and f) The RNA and protein levels of PD-L1 in TOV-21G and SKOV-3 cells were assessed by qPCR assay and western blotting. .

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