Tumor-Derived Exosome FGD5-AS1 Promotes Angiogenesis, Vascular Permeability, and Metastasis in Thyroid Cancer by Targeting the miR-6838-5p/VAV2 Axis

Figure 5

Identification of VAV2 as a miRNA target oncogene. (a) Predicted binding site information of miR-6838-5p to VAV2. (b) VAV2 wild-type (wt) and mutant (mut) luciferase reporter vector assays. (c) VAV2 is upregulated in TC tumors. (d) VAV2 expression is associated with poorer OS. The survival analysis data of VAV2 was downloaded from the open source database The Human Protein Atlas (http://www.proteinatlas.org/). (e) Pearson correlation analysis showed a correlation between miR-6838-5p and VAV2 expression (). (f) Pearson correlation analysis showing the correlation of FGD5-AS1 and VAV2 expression (). (g) qRT-PCR analysis shows that miR-6838-5p downregulates VAV2 in SW1736 and KAT18 cells. Data are presented as ().

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