Tumor-Derived Exosome FGD5-AS1 Promotes Angiogenesis, Vascular Permeability, and Metastasis in Thyroid Cancer by Targeting the miR-6838-5p/VAV2 Axis

<div>Exosomal FGD5-AS1 from TC SW1736 and KAT18 cells promotes angiogenesis in vitro. HUVECs were cocultured with SW1736/FGD5-AS1 exosomes, SW1736/NC exosomes, KAT18/FGD5-AS1 exosomes, and KAT18/NC exosomes. (a) Detection of miR-6838-5p expression in HUVECs after different treatments. (b) Detection of VAV2 expression after different treatments. (c) Detection of VEGF expression after different treatments. (d) Detection of VE-cadherin expression after different treatments. (e) Detection of ZO-1 expression after different treatments. (f) Detection of occludin expression after different treatments. (g) Detection of claudin5 expression after different treatments. (h) Effects of coculture of HUVECs with SW1736/FGD5-AS1 exosomes, SW1736/NC exosomes, KAT18/FGD5-AS1 exosomes, and KAT18/NC exosomes on migration. 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Journal of Oncology

fig6

Figure 6

Figure 6: Tumor-Derived Exosome FGD5-AS1 Promotes Angiogenesis, Vascular Permeability, and Metastasis in Thyroid Cancer by Targeting the miR-6838-5p/VAV2 Axis 

Figure 6 | Tumor-Derived Exosome FGD5-AS1 Promotes Angiogenesis, Vascular Permeability, and Metastasis in Thyroid Cancer by Targeting the miR-6838-5p/VAV2 Axis 