The Emerging Role of MTHFD Family Genes in Regulating the Tumor Immunity of Oral Squamous Cell Carcinoma

Table 1

The correlations between MTHFD family genes and clinical characteristics by logistic regression analysis.

Characteristics	MTHFD1			MTHFD1L			MTHFD2			MTHFD2L
	Total (N)	Odds Ratio (OR)	value	Total (N)	Odds Ratio (OR)	value	Total (N)	Odds Ratio (OR)	value	Total (N)	Odds Ratio (OR)	value
T stage (T3 and T4 versus T1 and T2)	319	1.309 (0.834–2.061)	0.243	319	1.282 (0.817–2.019)	0.281	319	1.733 (1.101–2.743)	0.018	319	1.474 (0.938–2.326)	0.093
N stage (N1, N2, and N3 versus N0)	315	1.456 (0.934–2.276)	0.098	315	1.123 (0.721–1.750)	0.609	315	1.378 (0.884–2.152)	0.157	315	1.119 (0.718–1.744)	0.619
M stage (M1 versus M0)	312	0.975 (0.038–24.791)	0.985	312	82002730.329 (0.000-NA)	0.996	312	1.026 (0.040–26.104)	0.985	312	0.000 (NA-2380550791035)	0.996
Clinical stage (Stage III and Stage IV versus Stage II and Stage I)	319	1.491 (0.914–2.446)	0.111	319	1.215 (0.746–1.985)	0.435	319	1.741 (1.064–2.872)	0.028	319	1.270 (0.780–2.078)	0.337
Radiation therapy (Yes versus No)	295	0.678 (0.423–1.084)	0.105	295	1.185 (0.742–1.894)	0.477	295	1.229 (0.770–1.967)	0.388	295	1.135 (0.711–1.816)	0.595
Primary therapy outcome (PD and SD versus CR and PR)	278	0.911 (0.460–1.798)	0.787	278	0.911 (0.460–1.798)	0.787	278	1.784 (0.900–3.637)	0.102	278	0.754 (0.377–1.485)	0.416
Gender (Male versus Female)	329	1.009 (0.632–1.611)	0.971	329	0.900 (0.563–1.437)	0.660	329	1.505 (0.942–2.418)	0.089	329	1.690 (1.056–2.723)	0.030
Race (Asian and Black or African American versus White)	318	1.363 (0.641–2.962)	0.423	318	1.826 (0.852–4.097)	0.129	318	1.586 (0.744–3.494)	0.238	318	1.459 (0.684–3.214)	0.334
Age (>60 versus ≤60)	328	0.951 (0.616–1.467)	0.820	328	0.999 (0.647–1.541)	0.995	328	1.340 (0.868–2.073)	0.187	328	0.611 (0.394–0.944)	0.027
Histologic grade (G3 and G4 versus G1 and G2)	321	1.126 (0.661–1.925)	0.662	321	1.848 (1.077–3.223)	0.027	321	1.566 (0.917–2.701)	0.102	321	1.046 (0.613–1.785)	0.869
Smoker (Yes versus No)	323	0.977 (0.597–1.599)	0.927	323	1.041 (0.636–1.704)	0.874	323	1.147 (0.701–1.879)	0.586	323	1.041 (0.636–1.704)	0.874
Alcohol history (Yes versus No)	321	1.079 (0.676–1.722)	0.751	321	1.119 (0.702–1.787)	0.636	321	1.352 (0.848–2.164)	0.206	321	1.490 (0.933–2.392)	0.096
Lymphovascular invasion (Yes versus No)	239	1.032 (0.597–1.786)	0.911	239	0.778 (0.449–1.344)	0.368	239	1.273 (0.736–2.213)	0.389	239	0.923 (0.533–1.595)	0.774
Lymph node neck dissection (No versus Yes)	327	1.143 (0.608–2.161)	0.678	327	1.143 (0.608–2.161)	0.678	327	1.045 (0.556–1.971)	0.890	327	1.588 (0.842–3.055)	0.157

The bold values means p value < 0.05, and the other unbold values mean p value > 0.05.