Hypoxia Confers Tumor with a Higher Immune Infiltration but Lower Mutation Burden in Gastrointestinal Cancer

Figure 4

A well-conceivedtwo-gene signature was identified that could predict the prognosis of gastrointestinal cancer patients. (a) Cross-validation for tuning parameter selection in the proportional hazards model. The left vertical dotted line displayed where the CV-error curve hit its minimum (lambda.min) and the right vertical dotted line showed us the most regularized model with CV-error within 1 standard deviation of the minimum (lambda.1se). (b) LASSO coefficient profiles of 1,021 prognosis-associated genes. (c) KM plot of gastrointestinal cancer patients with either high- or low-risk from TCGA after LASSO regression. (d) Validation of the risk model established by TCGA samples in GSE39582 and GSE62254 cohorts. (e) A multivariate Cox PH analysis including risk score, age, and sex of CRC and STAD patients from TCGA. (f) A multivariate Cox PH analysis including risk score, age, and sex of CRC and STAD patients from GEO. (g) The expression of HEYL and NRP1 in the high- or low-risk group is cut off by the median risk score in TCGA. (h) The expression of HEYL and NRP1 in the high- or low-risk group in GEO.

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