Risk of Rash in PD-1 or PD-L1-Related Cancer Clinical Trials: A Systematic Review and Meta-Analysis

Figure 3

Forest plots of comparison in combination regimens. (a) The OR of rash for all grades checked using the random effect (RE) model in Group B (PD-1 or PD-L1 plus Chemotherapy versus Chemotherapy): subgroup analyses were carried out according to the types of immune checkpoint inhibitors (PD-1 or PD-L1). (b) The OR of rash for all grades checked using the random effect (RE) model in Group B (PD-1 or PD-L1 plus Chemotherapy versus Chemotherapy): subgroup analyses were carried out according to the treatment lines (first or second line). (c) The OR of rash for all grades checked using the random effect (RE) model in Group B (PD-1 or PD-L1 plus Chemotherapy versus Chemotherapy): subgroup analyses were carried out based on tumor type. (d) The OR of rash for all grades checked using the random effect (RE) model in Group B (PD-1 or PD-L1 plus Chemotherapy versus Chemotherapy): subgroup analyses were carried out based on tumor type and immune checkpoint type. (e) The OR of rash for all-grade checked using the random effect (RE) model in Group C (Camrelizumab plus Chemotherapy versus Chemotherapy). (f) The OR of rash for all-grade checked using the random effect (RE) model in Group D (PD-1 or PD-L1 plus Chemotherapy plus Bevacizumab versus Chemotherapy plus Bevacizumab).

(a)

(b)

(c)

(d)

(e)

(f)