circRNA TCFL5 Promote Esophageal Cancer Progression by Modulating M2 Macrophage Polarization via the miR-543-FMNL2 Axis

Figure 6

Overexpression of circRNA TCFL5 promoted esophageal cancer progression in vivo. (a) The expression of circRNA TCFL5 was successfully upregulated or suppressed in xenograft tumors. (b) The tumor volume was remarkably higher with circRNA TCFL5 overexpression while lower with circRNA TCFL5 suppression than that in the NC group. (c) Ki-67 immunohistochemistry was used to detect the proliferation affected by circRNA TCFL5. (d) TUNEL analysis was used to detect the tumor cells with apoptosis affected by circRNA TCFL5. (e) qPCR analysis was used to detect the expression of miR-543 affected by circRNA TCFL5. (f, g) The expression of FMNL2 was detected by qRT-PCR and western blot affected by circRNA TCFL5, respectively. Data are shown as , , over-circRNA TCFL5 vs. NC group; ^##, Sh-circRNA TCFL5 vs. NC group.

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