Hesperidin Inhibits the p53-MDMXInteraction-Induced Apoptosis of Non-Small-Cell Lung Cancer and Enhances the Antitumor Effect of Carboplatin

Figure 1

Hesperetin induced the apoptosis of wild-type p53 NSCLC cells and inhibited the growth of NSCLC cells. (a) Structural formula of hesperetin. (b) TUNEL to detect A549 and NCI-H460 cell apoptosis (hesperidin: 10, 25, and 50 μM). (c) CCK-8 experiment to detect the changes in A549 and NCI-H460 cell viability. (d) Transwell test to detect the invasion ability of A549 and NCI-H460 cells. Error bars represent the standard deviations of three independent experiments. Scale bar = 100 μm. , P < 0.01. HPF: high-power field. Mean ± SD are shown, n = 3.

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