Hesperidin Inhibits the p53-MDMXInteraction-Induced Apoptosis of Non-Small-Cell Lung Cancer and Enhances the Antitumor Effect of Carboplatin

Figure 4

Hesperetin and Nutlin-3a (MDM inhibitor) synergistically inhibited p53-MDMX interaction. (a) MDMX expression detection after different treatments (Nutrin-3A: 10 μM; hesperidin: 10 μM). (b) Detection of the p53 expression after different treatments. (c) Detection of the p21 expression after different treatments. (d) PUMA expression detection after different treatments. (e) Bax expression detection after different treatments. (f) Bcl-2 expression detection after different treatments. Error bars represent the standard deviations of three independent experiments. , P < 0.01. Mean ± SD are shown, n = 3.

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