Hesperidin Inhibits the p53-MDMXInteraction-Induced Apoptosis of Non-Small-Cell Lung Cancer and Enhances the Antitumor Effect of Carboplatin

Figure 6

Hesperetin increased the antitumor activity of carboplatin by stabilizing p53. (a) Detection of the p53 expression after different treatments (carboplatin: 40 μM; hesperidin: 10 μM). (b) Detection of the p21 expression after different treatments. (c) PUMA expression detection after different treatments. (d) Bax expression detection after different treatments. (e) Bcl-2 expression detection after different treatments. Error bars represent the standard deviations of three independent experiments. , P < 0.01. Mean ± SD are shown, n = 3.

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