Sirtuin 4 Inhibits Prostate Cancer Progression and Metastasis by Modulating p21 Nuclear Translocation and Glutamate Dehydrogenase 1 ADP-Ribosylation

<div>SIRT4 suppresses cell proliferation, migration, and invasion through the ADP-ribosylation of GLUD1. (a–c) Cell proliferation ability was analyzed by CCK8 assay, colony formation assay, EdU assay with PC-3, and SIRT4-overexpressing PC-3 cells with or without being treated with nicotinamide. (d) The cell migration of PC-3 and PC-3-SIRT4 cells was measured after dealing with or without nicotinamide by wound-healing assay. (e) Effects of SIRT4 on migration and invasion abilities were detected by Transwell assay. 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Journal of Oncology

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Figure 6

Figure 6: Sirtuin 4 Inhibits Prostate Cancer Progression and Metastasis by Modulating p21 Nuclear Translocation and Glutamate Dehydrogenase 1 ADP-Ribosylation 

Figure 6 | Sirtuin 4 Inhibits Prostate Cancer Progression and Metastasis by Modulating p21 Nuclear Translocation and Glutamate Dehydrogenase 1 ADP-Ribosylation 