Sirtuin 4 Inhibits Prostate Cancer Progression and Metastasis by Modulating p21 Nuclear Translocation and Glutamate Dehydrogenase 1 ADP-Ribosylation

<div>Rescue experiments proved that SIRT4 plays it inhibitory role by affecting the p21 phosphorylation. (a, b). CCK-8 and colony formation assays showed that the enhanced proliferation ability of the 22rv1-shSIRT4 cell was blocked after Akt inhibition. (c) The results of the transwell assay demonstrated that MK-2206 inhibited the migration and invasion ability of SIRT4 silencing 22rv1 cells. (d) Western blotting was used to indicate that MK-2206 inhibited the activation of p21 phosphorylation. 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Journal of Oncology

fig7

Figure 7

Figure 7: Sirtuin 4 Inhibits Prostate Cancer Progression and Metastasis by Modulating p21 Nuclear Translocation and Glutamate Dehydrogenase 1 ADP-Ribosylation 

Figure 7 | Sirtuin 4 Inhibits Prostate Cancer Progression and Metastasis by Modulating p21 Nuclear Translocation and Glutamate Dehydrogenase 1 ADP-Ribosylation 