Sirtuin 4 Inhibits Prostate Cancer Progression and Metastasis by Modulating p21 Nuclear Translocation and Glutamate Dehydrogenase 1 ADP-Ribosylation

Figure 8

The schematic model shows that SIRT4 inhibits the proliferation, migration, and invasion of PCa cells in two ways, one is affecting p21 phosphorylation and its subcellular localization, and the other one is regulating glutamine metabolism by GLUD1 ADP-ribosylation.