Gene Expression Analysis Reveals Prognostic Biomarkers of the Tyrosine Metabolism Reprogramming Pathway for Prostate Cancer

Figure 3

Establishment of the molecular subgroup of prostate cancer. (a) The unsupervised hierarchical clustering method established the molecular subgroup of prostate cancer based on the expression of 19 tyrosine metabolism-related enzymes; (b) principal component analysis (PCA) showed the clustering of two molecular subgroups; (c) Kaplan–Meier plot and logrank analysis showed the survival difference between S1 and S2 subgroups; (d) univariate Cox regression analysis revealed the prognostic role of tyrosine metabolism-related genes in prostate cancer; (e) the differentially expressed genes between S2 and S1 subgroups; (f) GSEA revealed the difference between S2 and S1 subgroups at the pathway level.

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