A Lower HCC Incidence in Chronic HBV-Infected Patients Recovered from Acute-on-Chronic Liver Failure: A Prospective Cohort Study
Table 1
Baseline characteristics and follow-up summary of study patientsa.
Variables
Entire cohort
Propensity score match cohortdc
CLD-cohort (n = 380)
ACLF-treated cohort (n = 369)
CLD-cohort (n = 249)
ACLF-treated cohort (n = 249)
Gender
Female
68 (17.9)
54 (14.6)
0.227
42 (16.9)
35 (14.1)
0.386
Male
312 (82.1)
315 (85.4)
207 (83.1)
214 (85.9)
Age (years)b
40.5 (34.0–50.0)
42.0 (35.0–49.0)
0.505
42.0 (34.0–51.0)
42.0 (34.5–48.0)
0.130
Liver cirrhosis
No
278 (73.2)
141 (38.2)
<0 0.001
149 (59.8)
141 (56.6)
0.467
Yes
102 (26.8)
228 (61.8)
100 (40.2)
108 (43.4)
Family history of HCC
No
348 (91.6)
356 (96.5)
0.005
230 (92.4)
236 (94.8)
0.273
Yes
32 (8.4)
13 (3.5)
19 (7.6)
13 (5.2)
Alcohol consumption
No
317 (83.4)
257 (69.6)
<0.001
211 (84.7)
178 (72.1)
0.001
Yes
63 (16.6)
110 (29.8)
38 (15.3)
69 (27.9)
HBV DNA (log10 copies/mL)
<4.0
58 (15.3)
83 (22.5)
0.011
46 (18.5)
63 (25.3)
0.065
≥4.0
322 (84.7)
286 (77.5)
203 (81.5)
186 (74.7)
HBeAg status
Negative
190 (50.0)
127 (34.4)
<0.001
95 (46.8)
57 (30.6)
0.001
Positive
190 (50.0)
242 (65.6)
108 (53.2)
129 (69.4)
Total bilirubin (μmol/L)b
40.0 (21.0–135.0)
261.0 (203.3–349.6)
<0.001
47.0 (25.0–142.0)
271.3 (210.4–364.6)
<0.001
Albumin (g/L)b
36.0 (32.0–40.0)
29.0 (27.0–32.0)
<0.001
35.0 (31.0–39.0)
30.0 (27.0–33.0)
<0.001
Alanine aminotransferase (U/L)b
109.0 (47.0–319.0)
185.0 (91.0–547.0)
<0.001
88.0 (43.0–290.3)
214.0 (89.0–606.0)
<0.001
Aspartate aminotransferase (U/L)b
92.0 (54.0–191.0)
186.0 (116.0–376.0)
<0.001
82.5 (54.0–176.0)
199.0 (110.0–391.0)
<0.001
Platelet count (109/L)b
94.5 (51.8–140.3)
96.4 (66.5–126.0)
0.404
84.0 (47.8–136.3)
105.0 (76.7–131.0)
0.564
α-fetoprotein (ng/mL)b
17.0 (5.0–100.3)
80.1 (29.5–232.7)
0.543
17.0 (6.0–85.8)
71.0 (28.0–185.2)
0.764
Person-years of follow-up
3575.58
2598.39
2257.42
1718.31
Follow-up duration (years)
8.8 (6.3–12.3)
8.3 (4.0–9.7)
8.4 (6.2–12.0)
8.2 (3.0–9.6)
HCC cases
35
15
0.005
23
8
0.005
Notes.aData are number (%), unless otherwise indicated. Some percentages do not sum up to 100 because of rounding. bMedian (IQR). cVariables used in the model were age, gender, cirrhosis, and family history of HCC.
