Prognostic Utility of Platelet-to-Albumin Ratio among Critically Ill Patients with Colorectal Cancer: A Propensity Score Matching Study

Table 1

Comparison of baseline metrics between the low and high PAR groups.

Baseline metrics	Original cohort			Matched cohort			Validation cohort
	Low PAR	High PAR	P	Low PAR	High PAR	P	Low PAR	High PAR	p
Number	511	265	—	202	202	—	154	65	—
Age, years	70.1 (13.4)	68.1(13.6)	0.051	68.6 (14.1)	69.5 (12.8)	0.472	69.7 (12.0)	68.7 (15.2)	0.620
Gender, male, n (%)	320 (62.6)	137 (51.7)	0.004	113 (55.9)	107 (53.0)	0.617	98 (63.6)	28 (43.1)	0.008
BMI, kg/m^2	27.7 (7.9)	28.0 (8.3)	0.590	28.2 (8.4)	28.1 (8.3)	0.885	29.2 (8.4)	27.5 (8.3)	0.186
Ethnicity, n (%)			0.568			0.479			0.087
White	400 (78.3)	199 (75.1)		155 (76.7)	154 (76.2)		110 (71.4)	40 (61.5)
Black	66 (12.9)	41 (15.5)		33 (16.3)	28 (13.9)		19 (12.3)	6 (9.2)
Other	45 (8.8)	25 (9.4)		14 (6.9)	20 (9.9)		25 (16.2)	19 (29.2)
Interventions, n (%)
MV use	136 (26.6)	99 (37.4)	0.003	77 (38.1)	66 (32.7)	0.298	49 (31.8)	29 (44.6)	0.098
RRT use	6 (1.2)	3 (1.1)	1.000	1 (0.5)	1 (0.5)	1.000	7 (4.5)	0 (0.0)	0.185
Vasopressor use	75 (14.7)	48 (18.1)	0.093	33 (16.3)	32 (15.8)	1.000	57 (37.0)	23 (35.4)	0.940
Score system, points
SOFA	3.5 (1.0)	3.4 (1.1)	0.909	3.6 (1.2)	3.4 (1.2)	0.592	4.8 (1.5)	5.4 (1.4)	0.282
OASIS	23.6 (10.2)	26.7 (10.4)	0.001	26.1 (10.9)	26.7 (10.1)	0.716	31.9 (8.7)	35.2 (9.8)	0.013
APSIII	43.5 (12.5)	50.0 (24.1)	0.001	48.6 (14.6)	47.7 (14.8)	0.725	47.8 (21.1)	56.1 (25.0)	0.021
Comorbidities, n (%)
Hypertension	75 (14.7)	34 (12.8)	0.553	30 (14.9)	26 (12.9)	0.666	64 (41.6)	19 (29.2)	0.117
Diabetes	131 (25.6)	60 (22.6)	0.406	47 (23.3)	50 (24.8)	0.816	46 (29.9)	9 (13.8)	0.020
CKD	57 (11.2)	21 (7.9)	0.196	16 (7.9)	15 (7.4)	1.000	21 (13.6)	7 (10.8)	0.720
Myocardial infarct	41 (8.0)	16 (6.0)	0.390	16 (7.9)	16 (7.9)	1.000	25 (16.2)	6 (9.2)	0.252
CHF	64 (12.5)	20 (7.5)	0.046	24 (11.9)	15 (7.4)	0.178	35 (22.7)	11 (16.9)	0.434
COPD	63 (12.3)	32 (12.1)	1.000	22 (10.9)	23 (11.4)	1.000	30 (19.5)	18 (27.7)	0.245
Liver disease	11 (2.2)	2 (0.8)	0.253	1 (0.5)	1 (0.5)	1.000	16 (10.4)	4 (6.2)	0.461
CCI, points	5.7 (2.3)	5.4 (1.5)	0.191	5.5 (2.3)	5.5 (2.5)	0.965	8.9 (2.6)	9.0 (2.9)	0.670
Complications, n (%)
AKI	119 (23.3)	81 (30.6)	0.168	54 (26.7)	49 (24.3)	0.347	43 (27.9)	20 (30.8)	0.793
Sepsis	76 (14.9)	45 (17.0)	0.507	29 (14.4)	28 (13.9)	1.000	73 (47.4)	29 (44.6)	0.818
Vital signs
MAP, mmHg	87.1 (16.1)	87.9 (17.4)	0.548	88.9 (16.0)	87.7 (17.0)	0.464	83.0 (19.6)	81.6 (16.7)	0.623
Heart rate, bpm	89.2 (21.0)	93.9 (21.7)	0.004	92.4 (22.1)	92.2 (22.4)	0.934	96.5 (24.3)	100.6 (23.2)	0.248
RR, bpm	19.1 (5.0)	19.3 (5.4)	0.504	19.6 (5.7)	19.6 (5.4)	0.943	19.9 (5.4)	20.8 (6.3)	0.252
SpO2, %	96.9 (3.2)	96.6 (4.7)	0.080	96.6 (4.0)	96.7 (3.4)	0.687	95.8 (5.7)	97.0 (4.7)	0.137
Laboratory results
WBC, ×10^9/L	10.5 (4.0)	13.5 (5.8)	0.001	12.3 (4.8)	12.1 (4.7)	0.817	11.2 (4.3)	13.4 (4.8)	0.123
HGB, g/dL	11.2 (2.3)	10.1 (2.3)	0.001	10.4 (2.3)	10.4 (2.2)	0.898	10.4 (1.9)	9.8 (2.2)	0.033
PLT, ×10^9/L	186.7 (70.9)	388.2 (95.7)	0.001	195.1 (77.8)	370.9 (97.6)	<0.001	189.0 (64.3)	346.9 (94.9)	<0.001
HCT, %	34.1 (6.7)	31.5 (6.6)	0.001	32.3 (6.9)	32.3 (6.2)	0.973	32.5 (5.6)	31.0 (5.9)	0.070
Albumin, g/dL	3.5 (0.7)	2.9 (0.6)	0.001	3.5 (0.7)	2.9 (0.7)	<0.001	3.5 (0.6)	2.7 (0.7)	<0.001
PAR	5.4 (1.9)	14.0 (5.0)	0.001	5.6 (1.9)	13.4 (5.5)	<0.001	5.5 (1.8)	13.0 (4.0)	<0.001
ALP, U/L	138.5(64.9)	174.3 (72.7)	0.018	169.5 (65.4)	154.8(61.5)	0.501	132.7(68.90	132.1(67.2)	0.965
Bilirubin, mmol/L	1.2 (0.5)	1.3 (0.6)	0.504	1.3 (0.5)	1.2 (0.5)	0.612	1.6 (0.6)	1.1 (0.5)	0.217
Anion gap, mEq/L	10.8 (4.0)	12.0 (4.9)	0.001	11.5 (4.6)	11.2 (4.3)	0.445	14.7 (4.2)	15.5 (4.7)	0.221
Bicarbonate, mEq/L	24.0 (4.5)	24.2 (4.6)	0.504	24.2 (4.6)	24.4 (4.2)	0.569	22.8 (4.6)	22.6 (5.4)	0.783
BUN, mg/dL	22.9 (8.2)	24.9 (9.9)	0.166	24.1 (9.4)	23.1 (8.4)	0.593	24.2 (10.8)	25.6 (12.6)	0.662
Creatinine, mg/dL	1.3 (0.5)	1.4 (0.6)	0.254	1.4 (0.5)	1.4 (0.5)	0.628	1.3 (0.6)	1.2 (0.5)	0.572
Glucose, mg/dL	141.0(63.2)	131.4(50.2)	0.032	140.0(67.3)	133.1 (52.2)	0.249	144.9 (59.3)	133.5 (56.0)	0.189
Potassium, mmol/L	4.1 (0.7)	4.2 (0.9)	0.269	4.1 (0.9)	4.2 (0.8)	0.521	4.2 (0.9)	4.2 (0.7)	0.796
Sodium, mmol/L	137.2 (5.3)	136.2 (5.9)	0.022	136.2(6.2)	136.4(5.6)	0.783	137.4 (5.2)	137.8 (4.1)	0.579
Calcium, mg/dL	8.5 (1.1)	8.6 (0.9)	0.160	8.6 (1.0)	8.6 (0.9)	0.812	8.4 (0.7)	8.2 (0.6)	0.216
Chloride, mmol/L	103.3 (6.3)	101.4 (6.8)	0.001	101.8 (7.0)	102.1 (6.3)	0.725	102.7 (7.1)	102.3 (5.4)	0.704
PT, s	16.6 (7.8)	16.8 (7.3)	0.851	17.2 (7.3)	16.5 (7.4)	0.480	15.7 (5.3)	16.2 (5.7)	0.484
APTT, s	34.9 (10.7)	35.0 (8.0)	0.933	35.7 (11.6)	34.8 (7.8)	0.480	36.4 (10.8)	36.7 (11.7)	0.903
INR	1.5 (0.5)	1.5 (0.5)	0.686	1.5 (0.6)	1.5 (0.5)	0.577	1.4 (0.5)	1.5 (0.5)	0.526
Clinical outcome
LOS, days	10.9 (4.6)	12.2 (5.2)	0.109	12.2 (5.4)	12.0 (5.4)	0.838	11.7 (5.6)	10.9 (5.3)	0.606
Death, n (%)	42 (8.2)	65 (24.5)	0.001	20 (9.9)	55 (22.3)	0.001	15 (9.7)	23 (35.4)	<0.001