CAPRIN1 Enhances Chemoresistance and Glycolysis in Laryngeal Squamous Cell Carcinoma via Regulation of ZIC5

Figure 1

An elevation of CAPRIN1 was identified to be associated with chemoresistance and poor prognosis in laryngeal cancer. (a and b) Immunohistochemistry was used to determine the protein expressions of CAPRIN1 in laryngeal cancer tissues and adjacent normal tissues (ANT). Representative photographs were provided. Scale bars, 100 μm. (c) Besides, qRT-PCR was used to determine the mRNA expression levels of CAPRIN1 in laryngeal cancer tissues and ANT. (d) The Kaplan–Meier analysis was performed to compare the overall survival rate between the CAPRIN1 high group and CAPRIN1 low group from patients with laryngeal cancer (). (e and f) qRT-PCR and Western blotting were applied to determine the mRNA and protein expression levels of CAPRIN1 in laryngeal cancer cell lines including Hep-2 and TU-177 and cisplatin-resistant cells including Hep-2/R and TU-177/R as well as nasopharyngeal epithelial cells (NP69). ; .

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