CAPRIN1 Enhances Chemoresistance and Glycolysis in Laryngeal Squamous Cell Carcinoma via Regulation of ZIC5

<div>CAPRIN1 promoted glycolysis and chemoresistance of laryngeal cancer cells by the regulation of ZIC5. Hep-2 cells were transfected with pSin-vec plus si-NC, pSin-CAPRIN1 plus si-NC, or pSin-CAPRIN1 plus si-ZIC5. (a and b) qRT-PCR and Western blotting were used to determine the mRNA and protein expression levels of ZIC5. (c and d) Besides, the cellular uptake of 2-DOG and lactate secretion were determined. (e and f) qRT-PCR and Western blotting were used to determine the mRNA and protein levels of multidrug transporter expression (ABCG2 and ABCB1), respectively. (g and h) CCK-8 and colony formation assays were performed to determine cell viability in cisplatin-treated Hep-2 cells that were transfected. 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Journal of Oncology

fig6

Figure 6

Figure 6: CAPRIN1 Enhances Chemoresistance and Glycolysis in Laryngeal Squamous Cell Carcinoma via Regulation of ZIC5 