Methyltransferase-like 3 Aggravates HCC Development via Mediating N6-Methyladenosine of Ubiquitin-Specific Protease 7

<div>Upregulated METTL3 in hepatocellular carcinoma. (a) METTL3 expressions in liver cancer tissues and adjacent normal ones; (b) METTL3 expressions in HCC cell lines and the normal liver cell line; (c) protein level of METTL3 in 3 pairs of HCC tissues and adjacent normal ones; (d) the m6A content in total RNA of HCC tissues and adjacent normal ones; (e) m6A content of total RNA in HCC cell lines and the normal liver cell line (<svg height="11.7782pt" id="M16" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 52.1858 11.7782" width="52.1858pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M471 153C471 170 463 194 452 212C400 220 373 229 322 255C373 281 400 290 452 298C463 316 471 339 471 357C456 366 431 371 410 370C377 329 356 310 308 279C311 336 317 364 336 413C326 432 310 451 294 459C279 451 262 432 252 413C271 364 277 336 280 279C232 310 211 329 178 370C157 371 132 367 117 357C117 340 125 316 136 298C188 290 215 281 266 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Journal of Oncology

fig1

Figure 1

Figure 1: Methyltransferase-like 3 Aggravates HCC Development via Mediating N6-Methyladenosine of Ubiquitin-Specific Protease 7 