Methyltransferase-like 3 Aggravates HCC Development via Mediating N6-Methyladenosine of Ubiquitin-Specific Protease 7

<div>METTL3 was unfavorable to the prognosis of HCC. (a) Relative level of METTL3 in HCC patients with negative or positive lymphatic metastasis; (b) METTL3 expression in HCC patients with different tumor sizes; (c) relative level of METTL3 in HCC patients at different stages; (d) overall survival of HCC patients in high- or low-METTL3 groups (<svg height="11.7782pt" id="M18" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 52.1858 11.7782" width="52.1858pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M471 153C471 170 463 194 452 212C400 220 373 229 322 255C373 281 400 290 452 298C463 316 471 339 471 357C456 366 431 371 410 370C377 329 356 310 308 279C311 336 317 364 336 413C326 432 310 451 294 459C279 451 262 432 252 413C271 364 277 336 280 279C232 310 211 329 178 370C157 371 132 367 117 357C117 340 125 316 136 298C188 290 215 281 266 255C215 229 188 220 136 212C125 194 117 171 117 153C132 144 157 139 178 140C211 181 232 200 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Journal of Oncology

fig2

Figure 2

Figure 2: Methyltransferase-like 3 Aggravates HCC Development via Mediating N6-Methyladenosine of Ubiquitin-Specific Protease 7 