Methyltransferase-like 3 Aggravates HCC Development via Mediating N6-Methyladenosine of Ubiquitin-Specific Protease 7

Figure 4

METTL3 regulated USP7 by m6A methylation. (a) Prediction of m6A methylation in the USP7 gene; (b) USP7 expression in HCC tissues and adjacent normal ones; (c) METTL3 was positively correlated with USP7 in HCC tissues; (d) relative level of USP7 in Hep3B and Huh7 cells in different groups; (e) protein level of USP7 in Hep3B and Huh7 cells; (f) relative methylated level of USP7 in Hep3B and Huh7 cells in different groups; (g) USP7 expression in Hep3B and Huh7 cells in different groups; (h) METTL3 expression in Hep3B and Huh7 cells ( and ).

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