Ginsenoside Rg1 Inhibits High Glucose-Induced Proliferation, Migration, and Angiogenesis in Retinal Endothelial Cells by Regulating the lncRNA SNHG7/miR-2116-5p/SIRT3 Axis

<div>Rg1 affects the proliferation, migration and angiogenesis of HG-induced HRECs through miR-2116-5p/SIRT3. (a) CCK-8 assay of cell viability. qRT-PCR analysis of miR-2116-5p (b) and SIRT3 (c) expression. (D) Transwell assay of cell migration. (E) Comparison of angiogenesis in different groups. 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22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,61.187,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,67.427,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,73.667,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> compared to the HG group; <sup>##</sup><i>P</i> &lt; 0.01 and <sup>####</sup><i>P</i> &lt; 0.0001 compared Rg1 group; <sup>△</sup><i>P</i> &lt; 0.05, <sup>△△</sup><i>P</i> &lt; 0.01 and <sup>△△△△</sup><i>P</i> &lt; 0.0001 compared to the Rg1+miR-2116-5p mimic group.</div>

Journal of Oncology

fig6

Figure 6

Figure 6: Ginsenoside Rg1 Inhibits High Glucose-Induced Proliferation, Migration, and Angiogenesis in Retinal Endothelial Cells by Regulating the lncRNA SNHG7/miR-2116-5p/SIRT3 Axis 

Figure 6 | Ginsenoside Rg1 Inhibits High Glucose-Induced Proliferation, Migration, and Angiogenesis in Retinal Endothelial Cells by Regulating the lncRNA SNHG7/miR-2116-5p/SIRT3 Axis 