Knockdown of LINC01279 Suppresses Gastric Cancer Proliferation and Migration by Inhibiting PI3K/Akt/mTOR Signaling Pathway

<div>(a) Dataset GSE54129 from the GEO database was utilized to assess the differential expression of noncoding RNA in 111 GC tissues and 21 noncancerous gastric tissues. <svg height="12.7112pt" id="M21" style="vertical-align:-3.403299pt" version="1.1" viewbox="-0.0498162 -9.3079 117.852 12.7112" width="117.852pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M493 503C489 551 484 614 483 650H43V622C120 616 128 611 128 525V126C128 40 120 34 40 28V0H312V28C221 34 213 40 213 126V307H316C407 307 412 296 424 227H453V420H424C412 355 407 346 316 346H213V584C213 613 216 616 246 616H322C398 616 419 607 436 579C449 559 455 539 464 499L493 503Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.629,0)"><path d="M257 449C165 449 37 374 37 209C37 98 119 -12 256 -12C355 -12 473 65 473 226C473 349 381 449 257 449ZM244 416C333 416 380 320 380 204C380 67 329 21 267 21C184 21 130 115 130 241C130 354 184 416 244 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27V0H384Z"></path></g><g transform="matrix(.013,0,0,-0.013,71.868,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g></svg> are used as screening criteria to screen differentially expressed lncRNA; (b) differential expression of LINC01279 in 111 cases of GC tissues and 21 normal gastric tissues (GSE54129 data); (c) Kaplan-Meier plotter database <a href="http://kmplot.com/analysis/index.php?p=service&amp;cancer=gastric">http://kmplot.com/analysis/index.php?p=service&amp;cancer=gastric</a> is used to analyze the expression level effect of LINC01279 on the survival rate of 631 GC patients; (d) fluorescence quantitative PCR detects the LINC01279 expression in 70 cases of GC; (e) analyze the effect of LINC01279 expression on the survival of 70 gastric cancer patients; (f) fluorescence quantitative PCR detects the expression 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Journal of Oncology

fig1

Figure 1

Figure 1: Knockdown of LINC01279 Suppresses Gastric Cancer Proliferation and Migration by Inhibiting PI3K/Akt/mTOR Signaling Pathway 