Knockdown of LINC01279 Suppresses Gastric Cancer Proliferation and Migration by Inhibiting PI3K/Akt/mTOR Signaling Pathway

<div>Knockdown of LINC01279 induced the cell cycle arrest at G0/G1 phase in GC cells. (a) Flow cytometric analysis detected cell cycle distribution of LINC01279 knockdown on gastric cancer SGC-7901 and MGC-803 cells; (b, c) fluorescence quantitative PCR was used to detect the expression of G0/G1 phase-related regulatory proteins, such as p21, cyclin D1, CDK4, and CDK6. <span class="nowrap"><svg height="10.7395pt" id="M27" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 10.7395" width="50.9184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 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Journal of Oncology

fig3

Figure 3

Figure 3: Knockdown of LINC01279 Suppresses Gastric Cancer Proliferation and Migration by Inhibiting PI3K/Akt/mTOR Signaling Pathway 