A Novel Pseudogene Methylation Signature to Predict Temozolomide Outcome in Non-G-CIMP Glioblastomas

Table 1

Characteristics of the eight CpGs corresponding to seven pseudogenes.

Probe ID	Relevant pseudogene symbol	Chr.	Relation to gene region	Relation to CpGs island^a	Multivariate Cox coefficients^a
cg18311708	ZNF767P	7	TSS1500	Shore	1.584
cg22292345	NRADDP	3	TSS1500	Island	1.909
cg24257776	NRADDP	3	TSS1500	Island	1.635
cg03534453	PCDHB17P	5	Body	Shore	-2.824
cg07835270	MT1DP	16	TSS1500	Shore	-2.306
cg08409173	CLEC4GP1	19	Body	Island	-2.773
cg19089383	ADCY10P1	6	Body	Open Sea	-2.604
cg19500311	BMS1P4	10	Body	Shelf	-2.812

Chr = chromosome; TSS = transcriptional start site. ^aCox coefficients were calculated from multivariate analysis incorporating age, MGMT methylation status, and cohort source in meta-discovery cohorts of TCGA and GSE60274. ^bShore, shelf, and open sea referred to regions away from relevant CpGs islands less than 2000 base pairs, 2000~4000 base pairs, and more than 4000 base pairs, respectively.