A New Hypoxia-Related Prognostic Risk Score (HPRS) Model Was Developed to Indicate Prognosis and Response to Immunotherapy for Lung Adenocarcinoma

Figure 8

Construction of decision tree and nomogram for risk stratification of LUAD patients. (a): The decision tree based on LUAD clinicopathological variables (age, gender, T stage, N stage, M stage, and AJCC stage) in TCGA and HPRS. (b): The Kaplan–Meier curve of OS in four different risk subgroups. (c): HPRS distribution in each risk subgroup. (d): The proportion of survival and mortality included in the risk subgroup. (e, f): Univariate Cox regression and multivariate Cox regression of clinicopathological variables and HPRS. (g): A nomogram is constructed by combining the important clinical parameters obtained by univariate Cox regression and HPRS using multivariate Cox regression. (h): The calibration curve shows the accuracy of nomogram in predicting 1-, 3-, and 5-year OS in patients with LUAD. (i): The decision curve for important clinical parameters obtained from univariate Cox regression, HPRS, and nomogram. (j): The tROC curve of all the clinicopathological variables given in TCGA and HPRS and nomogram.

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