miRNA-331-3p Affects the Proliferation, Metastasis, and Invasion of Osteosarcoma through SOCS1/JAK2/STAT3

Figure 5

miR-331-3p inhibits SOCS1 leading to activation of the JAK2/STAT3 pathway. (a) OS cells transfected with miR-331-3p mimic/inhibitor. Protein expressions of JAK2, p-JAK2, STAT3, and p-STAT3 were examined by Western blot. (b) OS cells transfected with NC or miR-331-3p minic or cotransfected with miR-331-3p minic and the SOCS1 over-expression plasmid. Protein expressions of JAK2, p-JAK2, STAT3, and p-STAT3 were examined by Western blot.

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