A Pancancer Study of PIEZO1 as a Prognosis and Immune Biomarker of Human Tumors

Figure 8

Gene enrichment analysis of PIEZO1. (a) PIEZO1-binding proteins obtained from the STRING tool and displayed through STRING protein network map. (b) By using the GEPIA2 tool, the top 100 PIEZO1-associated genes were obtained. The correlations between PIEZO1 expression and top 5 representative genes (APRT, MFSD10, AGTRAP, MICALL2, and SYTL1) were explored by TCGA and/or GTEx. (c) The expression correlation data between PIEZO1 and APRT, MFSD10, AGTRAP, MICALL2, and SYTL1 in the TCGA tumors shown as heatmap. (d) The intersection of PIEZO1-binding and interacting genes after selection by Venn diagram analysis. (e-f) KEGG and GO enrichment analysis assessed based on PIEZO1-binding and interacted genes.