Genomic and Immunological Characterization of Pyroptosis in Lung Adenocarcinoma

Figure 3

Construction and evaluation of PPRS model. (a) A total of 73 promising candidates were identified among hub genes extracted from the red module. (b) 10 of the 73 genes were retained by application of LASSO-Cox regression model with a minimum of λ (λ = 0.0295). (c) FCRLB, COTL1, GNG10 and CASP4 were risk factors, while DOK1, CCR2 and AQP8 were protective factors. (d) PPRSs and corresponding living state of the samples obtained in ascending order and expression of 7 genes of the samples. (e) The survival rate of the high-PPRS group and the low-PPRS group in the TCGA-LUAD cohort. (f) The ROC curve of the PPRS model in the TCGA-LUAD cohort. (g) In cohorts GSE31210, the difference in OS and predictive efficacy was validated. (h): The difference in OS and predictive efficacy was validated for GSE31210 cohort. Log-rank test was conducted in (e g, and h).

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